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Abstract Details

Apathy and Parkinson’s Disease Motor Phenotypes: A Preliminary Study
Movement Disorders
P6 - Poster Session 6 (5:30 PM-6:30 PM)

Apathy is a common non-motor symptom of PD, characterized by decreased goal directed behavior. Apathy results in significant decline in functional abilities, caregiver burden, and increased costs of care. Motor phenotypes of PD are widely recognized (i.e., Postural Instability and Gait Difficulty [PIGD] and non-PIGD). It is unknown if distinct apathy profiles characterize motor PD phenotypes. DAS allows a multi-dimensional characterization of apathy (executive, emotional and cognitive/behavioral components) in addition to self-awareness.

To investigate apathy characteristics across Parkinson’s Disease (PD) motor phenotypes using the Dimensional Apathy Scale (DAS).

Eighteen participants (9 women, mean age: 64.5±9.5 years) with PD were recruited at Baylor College of Medicine under an IRB approved protocol. Apathy was measured by the DAS (cut off = 28.5), completed by both, participants and caregivers. Participants were also assessed with the Movement Disorders Society’s-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and the Montreal Cognitive Assessment (MoCA). Analyses were performed for the whole cohort and clinical subgroups (PIGD and non-PIGD). Statistical analyses were done by GraphPad Prism version9.0.

Seven participants were apathetic (PD-A) and 11 non-apathetic (PD-NA). There were no significant differences in age and MDS-UPDRS score between PD-A and PD-NA. The PD-A group had a significantly lower MoCA score (24.7±2.2 vs 27.4±2.5; p=0.03). In the whole cohort, there was a negative correlation between MoCA and total DAS score. DAS scores of participants and caregivers were correlated for the behavioral/cognitive and executive subscores but not for the emotional domain. Among those with PIGD-phenotype, 75% (3/4) had apathy versus 28.6% (4/14) among those with non-PIGD.

The prevalence of apathy in the PIGD subtype was higher. Discrepancy of emotional DAS scores between participants and caregivers may suggest domain specific deficits on self-awareness. Future work in a larger population will focus on the characterization of apathy across PD subtypes.
Abhishek Lenka (Baylor College of Medicine)
Mr. Lenka has nothing to disclose.
No disclosure on file
Nora Vanegas-Arroyave, MD (Baylor College of Medicine) The institution of Dr. Vanegas-Arroyave has received research support from National Institutes of Health. The institution of Dr. Vanegas-Arroyave has received research support from MJFF.