Abstract Details

Title Multiple Sclerosis-associated Cardiovascular Disease–Related Mortality: A Retrospective Cohort Study Using Real-world Data from the USA, 1999–2023

Topic Multiple Sclerosis

Presentation(s) P10 - Poster Session 10 (8:00 AM-9:00 AM)

Poster/Presentation
Number 18-002

Objective To investigate the mortality trends in adults in the United States specifically attributed to Multiple Sclerosis-associated Cardiovascular Disease (MS-CVD).

Background Cardiovascular disease represents a significant comorbidity and cause of mortality in individuals with MS. Despite known overlapping risk factors, comprehensive national mortality trends focusing on this specific association have not been extensively characterized.

Design/Methods We analyzed U.S. mortality data from CDC WONDER (1999–2023) for adults aged 25 and older. Deaths were identified where MS (ICD-10: G35) and cardiovascular disease (ICD-10: I00–I99) were listed as contributing or underlying causes. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Joinpoint regression was employed to determine annual percent change (APC) and average annual percent change (AAPC).

Results A total of 53,903 deaths from MS-CVD were recorded between 1999 and 2023 among adults aged 25 and older. The overall AAMR significantly increased from 0.78 in 1999 to 1.21 in 2023 (AAPC: 1.50, 95% CI: 1.13 to 1.86; p< 0.001), with an acceleration from 0.87 in 2018 to 1.24 in 2021 (APC: 12.83; p= 0.02). Sex-stratified analysis revealed higher mortality in women (35,157 deaths) compared to men (18,746 deaths), with women exhibiting higher AAMRs throughout the period (e.g., 1.45 in 2023 vs. 0.92 in men). Non-metropolitan regions had a higher overall AAMR (0.92) than metropolitan areas (0.88). While non-Hispanic White individuals accounted for the largest number of deaths (45,242), the non-Hispanic Black population showed the highest AAMR (1.59 in 2020). The +65 age group had the highest number of deaths (30,974) and a significant AAMR increase from 2.19 in 1999 to 4.17 in 2023.

Conclusions Mortality from MS-associated Cardiovascular Disease has significantly increased in the United States over the past 25 years. This upward trend is particularly pronounced in women, residents of non-metropolitan areas, and the non-Hispanic Black population, highlighting critical disparities in MS-CVD outcomes.

Authors/Disclosures
Mohamed F. Hemida Saleh PRESENTER	Dr. Hemida Saleh has nothing to disclose.
Alyaa Ahmed Ibrahim, MBBS (Alexandria Faculty of Medicine)	Dr. Ibrahim has nothing to disclose.
Mirna Hussein, MD	Dr. Hussein has nothing to disclose.
Mahmoud Tablawy, MD	Dr. Tablawy has nothing to disclose.
Maryam Saghir, MBBS	Miss Saghir has nothing to disclose.
Nafila Zeeshan, MBBS	Miss Zeeshan has nothing to disclose.
Ahmed Hamza, MD	Mr. Hamza has nothing to disclose.
Maliha Khalid, MBBS	Miss Khalid has nothing to disclose.
Eshal Saghir, MBBS	Miss Saghir has nothing to disclose.
Omar Rabie, Mbbch	Dr. Rabie has nothing to disclose.
Waheed Qaisi, MD	Dr. Qaisi has nothing to disclose.
Mostafa M. Alagamy, MD, PhD	Dr. Alagamy has nothing to disclose.
Muhammad Raza Sarfraz, MBBS	Dr. Sarfraz has nothing to disclose.
Amro Ali, MD	Dr. Ali has nothing to disclose.