Abstract Details

Title Trends in Alzheimer's Disease and Cardiac Arrest Related Mortality Among Older Adults in The United States – A CDC WONDER Analysis from 1999-2024

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P9 - Poster Session 9 (5:00 PM-6:00 PM)

Poster/Presentation
Number 12-007

Objective

This study examines long-term mortality trends and demographic disparities in Alzheimer disease and cardiac arrest related deaths in the United States from 1999 to 2024.

Background

Cardiac arrest is a frequent terminal event in Alzheimer disease, yet mortality trends capturing this overlap remain underexplored. As Alzheimer's prevalence grows with aging populations, understanding associated mortality patterns is critical for prevention and care planning.

Design/Methods

We analyzed death certificate data from the CDC WONDER database for adults ≥65 years using ICD-10 codes for Alzheimer's disease (G30.0, G30.1, G30.8, G30.9) and cardiac arrest (I46.0). Age-adjusted mortality rates (AAMRs) per 100,000 persons with 95% confidence intervals (CI) were standardized to the 2000 US population. Temporal patterns were assessed using joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC), stratified by sex, race, census region, urbanisation, and state.

Results Between 1999–2024, 306,002 deaths were identified. Most occurred in nursing homes (47.72%) and descendents homes (25.62%). The AAMR declined modestly from 26.21 in 1999 to 23.99 in 2024 (AAPC –0.51%, 95% CI: –1.43 to 0.42; p=0.281). Significant declines were noted in 2005–2013 (APC –2.86, p<0.001) and 2020–2024 (APC –4.86, p<0.001). Women bore the greatest burden than men (AAMR 29.16 vs. 23.25 ). Hispanics had the highest AAMR (38.12), followed by Non-Hispanic Black (29.32), Non-Hispanic Others (26.78), and Non-Hispanic Whites (25.77). Regionally, the West had the highest AAMR (54.92), while the Midwest was lowest (12.32). Urban residents had greater mortality rates than their rural counterparts (28.14 vs. 23.51). State variation ranged from California (AAMR 93.6) to Maryland (AAMR 2.8).

Conclusions

Alzheimer disease with cardiac arrest related mortality shows modest overall decline, but marked disparities persist by sex, race, geography, and care setting. Targeted prevention and resource allocation are needed to reduce inequities and improve end-of-life outcomes.

Authors/Disclosures
Shradha P. Kakde, MBBS PRESENTER	Dr. Kakde has nothing to disclose.
Arham Kamil, MBBS	Mr. Kamil has nothing to disclose.
Aiza Ahsan, MBBS	Dr. Ahsan has nothing to disclose.
Muhammad Izhan	Mr. Izhan has nothing to disclose.
Muhammad Babar Asad, MBBS	Dr. Asad has nothing to disclose.