EMBARGOED FOR RELEASE UNTIL 4 PM ET, June 23, 2003
Tip Sheet for the June 24, 2003 Neurology Journal
St. Paul, Minn. -
Patient Page tackles HIV-Associated Dementia HIV-associated dementia (HAD), the most common AIDS-related brain disorder, is the topic of a new “Patient Page” article on the Neurology journal website, www.neurology.org. (Online 6/24/03) The article describes for a lay public what HAD is, its symptoms, treatments, and new findings. The printed copy of the journal features an article by X. Luo, MD, of the First China Hospital Medical University in Shenyang, China, along with colleagues in the U.S. and Puerto Rico, theorizing that HAD is associated with the presence of MDM, an infection-fighting white blood cell. Watch for a news release on the Luo study by NIH, which funded the study. Lyme Disease featured Two scientific studies (both double-blind and placebo-controlled) and an editorial focusing on this chronic fatigue syndrome explore whether treating post-Lyme disease with antibiotics helps. It doesn’t, according to these papers. Editorial author Israel Steiner, MD, of Hadassah University Hospital in Jerusalem, Israel, poses the question whether post-Lyme exists: “Without an objective surrogate (preferably biological) marker to enable recruitment of homogenous study groups, every attempt to address clinical questions in the realm of post Lyme disease is doomed, almost per definition, to leave these questions unsettled.” Researchers identify possible link between insulin and dementia In a study led by researchers at medical schools in Seattle, WA, and Madison, WI, it was learned that insulin may warrant further study as a risk factor and potential therapeutic target of Alzheimer’s disease. IV infusion of insulin was found to acutely raise beta amyloid, the aggregation of which is a core neuropathologic feature of Alzheimer’s disease (AD), in the cerebrospinal fluid (CSF) of normal adults. CSF is a clear fluid that circulates in the space surrounding the spinal cord and brain. In a related editorial, Douglas Galasko, MD, UC-San Diego, notes that diabetes increases the risk of AD and this risk is highest in diabetics treated with insulin. Why? Diabetes causes vascular disease, which in turn worsens dementia; diabetes is associated with glycation of proteins, which could promote oxidative stress; there may be a link between amyloid and insulin in that insulin-degrading enzyme (IDE) also degrades soluble beta amyloid.